Ontology highlight
ABSTRACT:
SUBMITTER: Ni L
PROVIDER: S-EPMC6143921 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Immune system can recognize self vs transformed self. That is why cancer immunotherapy achieves notable benefits in a wide variety of cancers. Recently, several papers reported that immune checkpoint blockade therapy led to upregulation of IFNγ and in turn clearance of tumor cells. In this review, we conducted an extensive literature search of recent 5-year studies about the roles of IFNγ signaling in both tumor immune surveillance and immune evasion. In addition to well-known functions, IFNγ si ...[more]