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Interferon gamma in cancer immunotherapy.

ABSTRACT: Immune system can recognize self vs transformed self. That is why cancer immunotherapy achieves notable benefits in a wide variety of cancers. Recently, several papers reported that immune checkpoint blockade therapy led to upregulation of IFN? and in turn clearance of tumor cells. In this review, we conducted an extensive literature search of recent 5-year studies about the roles of IFN? signaling in both tumor immune surveillance and immune evasion. In addition to well-known functions, IFN? signaling also induces tumor ischemia and homeostasis program, resulting in tumor clearance and tumor escape, respectively. The yin and the yang of IFN? signaling are summarized. Thus, this review helps us to comprehensively understand the roles of IFN? in tumor immunity, which contributes to better design and management of clinical immunotherapy approaches.

SUBMITTER: Ni L

PROVIDER: S-EPMC6143921 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Interferon gamma in cancer immunotherapy.

Ni Ling L Lu Jian J

Cancer medicine 20180723 9

Immune system can recognize self vs transformed self. That is why cancer immunotherapy achieves notable benefits in a wide variety of cancers. Recently, several papers reported that immune checkpoint blockade therapy led to upregulation of IFNγ and in turn clearance of tumor cells. In this review, we conducted an extensive literature search of recent 5-year studies about the roles of IFNγ signaling in both tumor immune surveillance and immune evasion. In addition to well-known functions, IFNγ si ...[more]

PMID: 30039553

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