Ontology highlight
ABSTRACT:
SUBMITTER: Zaidi MR
PROVIDER: S-EPMC6350411 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20181109 1
Interferon-gamma (IFNG) has long been implicated as a central orchestrator of antitumor immune responses in the elimination stage of the immunoediting paradigm. However, mounting evidence suggests that IFNG may also have important and significant protumor roles to play in the equilibrium and escape phases through its regulatory effects on immunoevasive functions that promote tumorigenesis. These seemingly contradictory effects of IFNG undoubtedly play profound roles in not only the activation of ...[more]