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Intraoperative fluorescence imaging in thoracic surgery.

ABSTRACT: Intraoperative fluorescence imaging (IFI) can improve real-time identification of cancer cells during an operation. Phase I clinical trials in thoracic surgery have demonstrated that IFI with second window indocyanine green (TumorGlow® ) can identify subcentimeter pulmonary nodules, anterior mediastinal masses, and mesothelioma, while the use of a folate receptor-targeted near-infrared agent, OTL38, can improve the specificity for diagnosing tumors with folate receptor expression. Here, we review the existing preclinical and clinical data on IFI in thoracic surgery.

SUBMITTER: Newton AD

PROVIDER: S-EPMC6146026 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Intraoperative fluorescence imaging in thoracic surgery.

Newton Andrew D AD Predina Jarrod D JD Nie Shuming S Low Philip S PS Singhal Sunil S

Journal of surgical oncology 20180811 2

Intraoperative fluorescence imaging (IFI) can improve real-time identification of cancer cells during an operation. Phase I clinical trials in thoracic surgery have demonstrated that IFI with second window indocyanine green (TumorGlow<sup>®</sup> ) can identify subcentimeter pulmonary nodules, anterior mediastinal masses, and mesothelioma, while the use of a folate receptor-targeted near-infrared agent, OTL38, can improve the specificity for diagnosing tumors with folate receptor expression. Her ...[more]

PMID: 30098293

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