Genetics of the extracellular matrix in aortic aneurysmal diseases.
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ABSTRACT:
SUBMITTER: Lin CJ
PROVIDER: S-EPMC6146054 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Publications
Genetics of the extracellular matrix in aortic aneurysmal diseases.
Lin Chien-Jung CJ Lin Chieh-Yu CY Stitziel Nathan O NO
Matrix biology : journal of the International Society for Matrix Biology 20180412
Aortic aneurysms are morbid conditions that can lead to rupture or dissection and are categorized as thoracic (TAA) or abdominal aortic aneurysms (AAA) depending on their location. While AAA shares overlapping risk factors with atherosclerotic cardiovascular disease, TAA exhibits strong heritability. Human genetic studies in the past two decades have successfully identified numerous genes involved in both familial and sporadic forms of aortic aneurysm. In this review we will discuss the genetic ...[more]
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