Ontology highlight
ABSTRACT:
SUBMITTER: Yao R
PROVIDER: S-EPMC6146296 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Yao Ruosi R Sun Xiaoyang X Xie Yu Y Sun Xiaoshen X Yao Yao Y Li Hujun H Li Zhenyu Z Gao Jian J Xu Kailin K
Bioscience reports 20180919 5
Increasing evidence shows that c-Myc oncoprotein is tightly associated with multiple myeloma (MM) progression. Herein, we identified compound 7594-0035, which is a novel inhibitor that specifically targets c-Myc. It was identified from the ChemDiv compound database by molecular docking-based, high-throughput virtual screening. Compound 7594-0035 inhibited MM cell proliferation <i>in vitro</i>, induced cell cycle G<sub>2</sub>-phase arrest, and triggered MM cell death by disturbing the stability ...[more]