Ontology highlight
ABSTRACT:
SUBMITTER: Peng D
PROVIDER: S-EPMC6147121 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Peng Danyi D Si Daozhu D Zhang Rong R Liu Jiang J Gou Hao H Xia Yunqiu Y Tian Daiyin D Dai Jihong J Yang Ke K Liu Enmei E Shi Yujun Y Lu Q Richard QR Zou Lin L Fu Zhou Z
Genes & diseases 20171025 4
Alveolar epithelial cells (AECs) injury and failed reconstitution of the AECs barrier are both integral to alveolar flooding and subsequent pulmonary fibrosis (PF). Nevertheless, the exact mechanisms regulating the regeneration of AECs post-injury still remain unclear. SMARCA4 is a part of the large ATP-dependent chromatin remodelling complex SWI/SNF, which is essential for kidney and heart fibrosis. We investigates SMARCA4 function in lung fibrosis by establishing PF mice model with bleomycin f ...[more]