Ontology highlight
ABSTRACT:
SUBMITTER: Vincent-Mistiaen Z
PROVIDER: S-EPMC6147738 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Vincent-Mistiaen Zoé Z Elbediwy Ahmed A Vanyai Hannah H Cotton Jennifer J Stamp Gordon G Nye Emma E Spencer-Dene Bradley B Thomas Gareth J GJ Mao Junhao J Thompson Barry B
eLife 20180920
Squamous cell carcinoma (SCC) can progress to malignant metastatic cancer, including an aggressive subtype known as spindle cell carcinoma (spSCC). spSCC formation involves epithelial-to-mesenchymal transition (EMT), yet the molecular basis of this event remains unknown. The transcriptional co-activator YAP undergoes recurrent amplification in human SCC and overexpression of YAP drives SCC formation in mice. Here, we show that human spSCC tumours also feature strong nuclear localisation of YAP a ...[more]