P53 cooperates with SIRT6 to regulate cardiolipin de novo biosynthesis.
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ABSTRACT:
SUBMITTER: Li M
PROVIDER: S-EPMC6148051 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Publications
p53 cooperates with SIRT6 to regulate cardiolipin de novo biosynthesis.
Li Meiting M Hou Tianyun T Gao Tian T Lu Xiaopeng X Yang Qiaoyan Q Zhu Qian Q Li Zhiming Z Liu Chaohua C Mu Guanqun G Liu Ge G Bao Yantao Y Wen He H Wang Lina L Wang Haiying H Zhao Ying Y Gu Wei W Yang Yang Y Zhu Wei-Guo WG
Cell death & disease 20180920 10
The tumor suppressor p53 has critical roles in regulating lipid metabolism, but whether and how p53 regulates cardiolipin (CL) de novo biosynthesis is unknown. Here, we report that p53 physically interacts with histone deacetylase SIRT6 in vitro and in vivo, and this interaction increases following palmitic acid (PA) treatment. In response to PA, p53 and SIRT6 localize to chromatin in a p53-dependent manner. Chromatin p53 and SIRT6 bind the promoters of CDP-diacylglycerol synthase 1 and 2 (CDS1 ...[more]
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