Ontology highlight
ABSTRACT:
SUBMITTER: Mendoza PA
PROVIDER: S-EPMC6149462 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Mendoza Pablo A PA Silva Patricio P Díaz Jorge J Arriagada Cecilia C Canales Jimena J Cerda Oscar O Torres Vicente A VA
Cell adhesion & migration 20171106 3
The early endosome protein Rab5 was recently shown to promote cell migration by enhancing focal adhesion disassembly through mechanisms that remain elusive. Focal adhesion disassembly is associated to proteolysis of talin, in a process that requires calpain2. Since calpain2 has been found at vesicles and endosomal compartments, we hypothesized that Rab5 stimulates calpain2 activity, leading to enhanced focal adhesion disassembly in migrating cells. We observed that calpain2 co-localizes with EEA ...[more]