Ontology highlight
ABSTRACT:
SUBMITTER: Chan CO
PROVIDER: S-EPMC6149814 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Chan Chi-On CO Jing Jing J Xiao Wei W Tan Zhexu Z Lv Qiuyue Q Yang Jingyu J Chen Sibao S
Molecules (Basel, Switzerland) 20171129 12
Bufalin (BFL) has excellent physiological activities such as defending tumors, improving cardiac function, and so on. However, due to its poor water-solubility and bioavailability, the clinical application of BFL remains limited. In order to improve bioavailability of BFL, in our previous research, a novel peptide-dendrimer (PD) was synthesized and applied to encapsulate BFL. In the present study, we investigate the absorption property and mechanism of BFL in free form and BFL-peptide-dendrimer ...[more]