Ontology highlight
ABSTRACT:
SUBMITTER: Perez-Sanchez A
PROVIDER: S-EPMC6480586 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Pérez-Sánchez Almudena A Cuyàs Elisabet E Ruiz-Torres Verónica V Agulló-Chazarra Luz L Verdura Sara S González-Álvarez Isabel I Bermejo Marival M Joven Jorge J Micol Vicente V Bosch-Barrera Joaquim J Menendez Javier A JA
International journal of molecular sciences 20190331 7
An ever-growing number of preclinical studies have investigated the tumoricidal activity of the milk thistle flavonolignan silibinin. The clinical value of silibinin as a bona fide anti-cancer therapy, however, remains uncertain with respect to its bioavailability and blood⁻brain barrier (BBB) permeability. To shed some light on the absorption and bioavailability of silibinin, we utilized the Caco-2 cell monolayer model of human intestinal absorption to evaluate the permeation properties of thre ...[more]