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Anticancer and Immunogenic Properties of Cardiac Glycosides.

ABSTRACT: Cardiac glycosides (CGs) are natural compounds widely used in the treatment of several cardiac conditions and more recently have been recognized as potential antitumor compounds. They are known to be ligands for Na/K-ATPase, which is a promising drug target in cancer. More recently, in addition to their antitumor effects, it has been suggested that CGs activate tumor-specific immune responses. This review summarizes the anticancer aspects of CGs as new strategies for immunotherapy and drug repositioning (new horizons for old players), and the possible new targets for CGs in cancer cells.

SUBMITTER: Schneider NFZ

PROVIDER: S-EPMC6150164 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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Anticancer and Immunogenic Properties of Cardiac Glycosides.

Schneider Naira Fernanda Zanchett NFZ Cerella Claudia C Simões Cláudia Maria Oliveira CMO Diederich Marc M

Molecules (Basel, Switzerland) 20171108 11

Cardiac glycosides (CGs) are natural compounds widely used in the treatment of several cardiac conditions and more recently have been recognized as potential antitumor compounds. They are known to be ligands for Na/K-ATPase, which is a promising drug target in cancer. More recently, in addition to their antitumor effects, it has been suggested that CGs activate tumor-specific immune responses. This review summarizes the anticancer aspects of CGs as new strategies for immunotherapy and drug repos ...[more]

PMID: 29117117

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