Ontology highlight
ABSTRACT:
SUBMITTER: Xu Y
PROVIDER: S-EPMC6150263 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Xu Yiming Y Wu Lichuan L Dai Hang H Gao Mingyan M Ur Rashid Haroon H Wang Haodong H Xie Peng P Liu Xu X Jiang Jun J Wang Lisheng L
Molecules (Basel, Switzerland) 20171114 11
Using sophoridine <b>1</b> and chalcone <b>3</b> as the lead compounds, a series of novel α, β-unsaturated sophoridinic derivatives were designed, synthesized, and evaluated for their in vitro cytotoxicity. Structure-activity relationship (SAR) analysis indicated that introduction of α, β-unsaturated ketone moiety and heterocyclic group might significantly enhance anticancer activity. Among the compounds, <b>2f</b> and <b>2m</b> exhibited potential effects against HepG-2 and CNE-2 human cancer c ...[more]