Ontology highlight
ABSTRACT:
SUBMITTER: Onoabedje EA
PROVIDER: S-EPMC7904193 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Onoabedje Efeturi A EA Ibezim Akachukwu A Okoro Uchechukwu C UC Batra Sanjay S
PloS one 20210224 2
Carboxamides bearing sulphonamide functionality have been shown to exhibit significant lethal effect on Plasmodium falciparum, the causative agent of human malaria. Here we report the synthesis of thirty-two new drug-like sulphonamide pyrolidine carboxamide derivatives and their antiplasmodial and antioxidant capabilities. In addition, molecular docking was used to check their binding affinities for homology modelled P. falciparum N-myristoyltransferase, a confirmed drug target in the pathogen. ...[more]