Insulin and glucose homeostasis in childhood cancer survivors treated with abdominal radiation: A pilot study.

ABSTRACT:

Background

Childhood cancer survivors exposed to abdominal radiation (abdRT) are at increased risk for both insulin-dependent and non-insulin-dependent diabetes. We sought to clarify the pathophysiology of diabetes after abdRT by performing dynamic studies of insulin and glucose and testing for type 1 diabetes-associated autoantibodies.

Procedure

Cross-sectional analysis of 2-year childhood cancer survivors treated with abdRT at age ≤21 years who underwent oral glucose tolerance testing and assessment of diabetes-related autoantibodies from December 2014 to September 2016. Prevalence of insulin/glucose derangements, indices of insulin sensitivity/secretion (homeostatic model assessment of insulin resistance [HOMA-IR], whole-body insulin sensitivity, insulinogenic index), aut

SUBMITTER: Friedman DN 

PROVIDER: S-EPMC6150783 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature