Ontology highlight
ABSTRACT:
SUBMITTER: Park JE
PROVIDER: S-EPMC6151281 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Park Ji Eun JE Miller Zachary Z Jun Yearin Y Lee Wooin W Kim Kyung Bo KB
Translational research : the journal of laboratory and clinical medicine 20180326
Over 2 decades ago, the proteasome was considered a risky or even untenable therapeutic target. Today, proteasome inhibitors are a mainstay in the treatment of multiple myeloma (MM) and have sales in excess of 3 billion US dollars annually. More importantly, the availability of proteasome inhibitors has greatly improved the survival and quality of life for patients with MM. Despite the remarkable success of proteasome inhibitor therapies to date, the potential for improvement remains, and the de ...[more]