Ontology highlight
ABSTRACT:
SUBMITTER: Collins MK
PROVIDER: S-EPMC7486540 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
American journal of clinical and experimental urology 20200815 4
Within the last decade, bromodomain and extraterminal (BET) domain inhibitors were introduced as the first in a wave of new agents known as bromodomain inhibitors. These original examples exhibited anti-inflammatory and anticancer properties, and some have progressed to human clinical trials. BET proteins and their conserved N-terminal bromodomains, BD1 and BD2, have been implicated in the regulation of transcription. The early-generation BET inhibitors showed equal affinity for BD1 and BD2, and ...[more]