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Four Prenylflavone Derivatives with Antiplasmodial Activities from the Stem of Tephrosia purpurea subsp. leptostachya.

ABSTRACT: Four new flavones with modified prenyl groups, namely (E)-5-hydroxytephrostachin (1), purleptone (2), (E)-5-hydroxyanhydrotephrostachin (3), and terpurlepflavone (4), along with seven known compounds (5-11), were isolated from the CH?Cl?/MeOH (1:1) extract of the stem of Tephrosia purpurea subsp. leptostachya, a widely used medicinal plant. Their structures were elucidated on the basis of NMR spectroscopic and mass spectrometric evidence. Some of the isolated compounds showed antiplasmodial activity against the chloroquine-sensitive D6 strains of Plasmodium falciparum, with (E)-5-hydroxytephrostachin (1) being the most active, IC₅₀ 1.7 ± 0.1 ?M, with relatively low cytotoxicity, IC₅₀ > 21 ?M, against four cell-lines.

SUBMITTER: Atilaw Y

PROVIDER: S-EPMC6151588 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

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Four Prenylflavone Derivatives with Antiplasmodial Activities from the Stem of Tephrosia purpurea subsp. leptostachya.

Atilaw Yoseph Y Muiva-Mutisya Lois L Ndakala Albert A Akala Hoseah M HM Yeda Redemptah R Wu Yu J YJ Coghi Paolo P Wong Vincent K W VKW Wong Vincent K W VKW Erdélyi Máté M Yenesew Abiy A

Molecules (Basel, Switzerland) 20170910 9

Four new flavones with modified prenyl groups, namely (E)-5-hydroxytephrostachin (1), purleptone (2), (E)-5-hydroxyanhydrotephrostachin (3), and terpurlepflavone (4), along with seven known compounds (5-11), were isolated from the CH₂Cl₂/MeOH (1:1) extract of the stem of Tephrosia purpurea subsp. leptostachya, a widely used medicinal plant. Their structures were elucidated on the basis of NMR spectroscopic and mass spectrometr ...[more]

PMID: 28891957

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