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Cholesterol Flip-Flop Impacts Domain Registration in Plasma Membrane Models.

ABSTRACT: The plasma membrane is a highly complex multicomponent system that is central to the functioning of cells. Cholesterol, a key lipid component of the plasma membrane, promotes the formation of nanodomains. These nanodomains are often correlated across the two membrane leaflets, but the underlying physical mechanism remains unclear. Using coarse-grained molecular dynamics simulations, we investigate the influence of cholesterol flip-flop on membrane properties, in particular, the interleaflet coupling of cholesterol-enriched domains. We show that the cholesterol density correlation between the leaflets of an average mammalian plasma membrane is significantly reduced by suppressing interleaflet cholesterol population. Our results suggest an amplifying role of cholesterol in signal transduction across the leaflets.

SUBMITTER: Thallmair S

PROVIDER: S-EPMC6151656 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Cholesterol Flip-Flop Impacts Domain Registration in Plasma Membrane Models.

Thallmair Sebastian S Ingólfsson Helgi I HI Marrink Siewert J SJ

The journal of physical chemistry letters 20180911 18

The plasma membrane is a highly complex multicomponent system that is central to the functioning of cells. Cholesterol, a key lipid component of the plasma membrane, promotes the formation of nanodomains. These nanodomains are often correlated across the two membrane leaflets, but the underlying physical mechanism remains unclear. Using coarse-grained molecular dynamics simulations, we investigate the influence of cholesterol flip-flop on membrane properties, in particular, the interleaflet coup ...[more]

PMID: 30192549

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