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Transmembrane migration ('flip-flop') of cholesterol in erythrocyte membranes.


ABSTRACT: After exchange with [14C]cholesterol-labelled plasma lipoproteins for 0.5-4h, erythrocytes were extracted with bile-salt solutions. The extracted cholesterol (mainly from the outside of the erythrocyte membrane) had the same specific radioactivity as the residual sterol. Thus cholesterol equilibrates rapidly (half-time less than 1 h) between the two sides of the membrane.

SUBMITTER: Kirby C 

PROVIDER: S-EPMC1183808 | biostudies-other | 1977 Dec

REPOSITORIES: biostudies-other

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