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Efficient Approach to Carbinol Derivatives through Palladium-Catalyzed Base-Free Addition of Aryltriolborates to Aldehydes.

ABSTRACT: Palladium-catalyzed base-free addition of aryltriolborates to aldehydes has been developed, leading to a wide range of carbinol derivatives in good to excellent yields. The efficiency of this transformation was demonstrated by compatibility with a wide range of functional groups. The present synthetic route to carbinol derivatives could be readily scaled up to gram quantity without difficulty. Thus, this method represents a simple and practical procedure to access carbinol derivatives.

SUBMITTER: Hu K

PROVIDER: S-EPMC6151780 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

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Efficient Approach to Carbinol Derivatives through Palladium-Catalyzed Base-Free Addition of Aryltriolborates to Aldehydes.

Hu Kun K Ye Pengqing P Zhen Qianqian Q Yao Xinrong X Xu Tong T Shao Yinlin Y Chen Jiuxi J

Molecules (Basel, Switzerland) 20170920 9

Palladium-catalyzed base-free addition of aryltriolborates to aldehydes has been developed, leading to a wide range of carbinol derivatives in good to excellent yields. The efficiency of this transformation was demonstrated by compatibility with a wide range of functional groups. The present synthetic route to carbinol derivatives could be readily scaled up to gram quantity without difficulty. Thus, this method represents a simple and practical procedure to access carbinol derivatives. ...[more]

PMID: 28930180

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