Ontology highlight
ABSTRACT:
SUBMITTER: Li B
PROVIDER: S-EPMC6152180 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Li Bo B Huang Ai-Ling AL Zhang Yi-Long YL Li Zeng Z Ding Hai-Wen HW Huang Cheng C Meng Xiao-Ming XM Li Jun J
Molecules (Basel, Switzerland) 20170626 7
In this study we designed and synthesized a series of new hesperetin derivatives on the basis of the structural characteristics of acetylcholinesterase (AChE) dual-site inhibitors. The activity of the novel derivatives was also evaluated. Results showed that the synthesized hesperetin derivatives displayed stronger inhibitory activity against AChE and higher selectivity than butyrylcholine esterase (BuChE) (selectivity index values from 68 to 305). The Lineweaver-Burk plot and molecular docking ...[more]