Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC6832651 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Zhang Yilong Y Zheng Yan Y Shi Wen W Guo Yahui Y Xu Tao T Li Zeng Z Huang Cheng C Li Jun J
Molecules (Basel, Switzerland) 20191011 20
To develop new anti-inflammatory agents, a series of 7-<i>O</i>-amide hesperetin derivatives was designed, synthesized and evaluated for anti-inflammatory activity using RAW264.7 cells. All compounds showed inhibitory effect on LPS-induced NO production. Among them, 7-<i>O</i>-(2-(Propylamino)-2-oxoethyl)hesperetin (<b>4d</b>) and 7-<i>O</i>-(2-(Cyclopentylamino)-2-oxoethyl)hesperetin (<b>4k</b>) with hydrophobic side chains exhibited the most potent NO inhibitory activity (IC<sub>50</sub> = 19. ...[more]