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A Novel Brominated Alkaloid Securidine A, Isolated from the Marine Bryozoan Securiflustra securifrons.

ABSTRACT: A novel brominated alkaloid, Securidine A, was isolated from the cold water marine bryozoan Securiflustra securifrons. Securidine A was isolated using semi-preparative HPLC, and the structure was elucidated by spectroscopic methods. The isolated Securidine A was tested for cytotoxic, antibacterial, and anti-diabetic activities as well as for its potential for inhibition of biofilm formation. No significant biological activity was observed in the applied bioassays, thus expanded bioactivity profiling is required, in order to reveal any potential applications for Securidine A.

SUBMITTER: Michael P

PROVIDER: S-EPMC6152195 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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A Novel Brominated Alkaloid Securidine A, Isolated from the Marine Bryozoan Securiflustra securifrons.

Michael Priyanka P Hansen Kine Ø KØ Isaksson Johan J Andersen Jeanette H JH Hansen Espen E

Molecules (Basel, Switzerland) 20170723 7

A novel brominated alkaloid, Securidine A, was isolated from the cold water marine bryozoan <i>Securiflustra securifrons</i>. Securidine A was isolated using semi-preparative HPLC, and the structure was elucidated by spectroscopic methods. The isolated Securidine A was tested for cytotoxic, antibacterial, and anti-diabetic activities as well as for its potential for inhibition of biofilm formation. No significant biological activity was observed in the applied bioassays, thus expanded bioactivit ...[more]

PMID: 28737700

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