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Multidrug-resistant Neisseria gonorrhoeae failing treatment with ceftriaxone and doxycycline in France, November 2017.

ABSTRACT: We report a multidrug-resistant Neisseria gonorrhoeae urogenital and pharyngeal infection with ceftriaxone resistance and intermediate resistance to azithromycin in a heterosexual woman in her 20s in France. Treatment with ceftriaxone plus doxycycline failed for the pharyngeal localisation. Whole-genome sequencing of isolate F90 identified MLST1903, NG-MAST ST3435, NG-STAR233, and relevant resistance determinants. F90 showed phenotypic and genotypic similarities to an internationally spreading multidrug-resistant and ceftriaxone-resistant clone detected in Japan and subsequently in Australia, Canada and Denmark.

SUBMITTER: Poncin T 

PROVIDER: S-EPMC6152217 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Multidrug-resistant <i>Neisseria gonorrhoeae</i> failing treatment with ceftriaxone and doxycycline in France, November 2017.

Poncin Thibault T   Fouere Sebastien S   Braille Aymeric A   Camelena Francois F   Agsous Myriem M   Bebear Cecile C   Kumanski Sylvain S   Lot Florence F   Mercier-Delarue Severine S   Ngangro Ndeindo Ndeikoundam NN   Salmona Maud M   Schnepf Nathalie N   Timsit Julie J   Unemo Magnus M   Bercot Beatrice B  

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 20180501 21

We report a multidrug-resistant <i>Neisseria gonorrhoeae</i> urogenital and pharyngeal infection with ceftriaxone resistance and intermediate resistance to azithromycin in a heterosexual woman in her 20s in France. Treatment with ceftriaxone plus doxycycline failed for the pharyngeal localisation. Whole-genome sequencing of isolate F90 identified MLST<sub>1903</sub>, NG-MAST ST<sub>3435</sub>, NG-STAR<sub>233</sub>, and relevant resistance determinants. F90 showed phenotypic and genotypic simila  ...[more]

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