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Multidrug-resistant Neisseria gonorrhoeae failing treatment with ceftriaxone and doxycycline in France, November 2017.

ABSTRACT: We report a multidrug-resistant Neisseria gonorrhoeae urogenital and pharyngeal infection with ceftriaxone resistance and intermediate resistance to azithromycin in a heterosexual woman in her 20s in France. Treatment with ceftriaxone plus doxycycline failed for the pharyngeal localisation. Whole-genome sequencing of isolate F90 identified MLST1903, NG-MAST ST3435, NG-STAR233, and relevant resistance determinants. F90 showed phenotypic and genotypic similarities to an internationally spreading multidrug-resistant and ceftriaxone-resistant clone detected in Japan and subsequently in Australia, Canada and Denmark.

SUBMITTER: Poncin T

PROVIDER: S-EPMC6152217 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Multidrug-resistant Neisseria gonorrhoeae failing treatment with ceftriaxone and doxycycline in France, November 2017.

Poncin Thibault T Fouere Sebastien S Braille Aymeric A Camelena Francois F Agsous Myriem M Bebear Cecile C Kumanski Sylvain S Lot Florence F Mercier-Delarue Severine S Ngangro Ndeindo Ndeikoundam NN Salmona Maud M Schnepf Nathalie N Timsit Julie J Unemo Magnus M Bercot Beatrice B

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 20180501 21

We report a multidrug-resistant Neisseria gonorrhoeae urogenital and pharyngeal infection with ceftriaxone resistance and intermediate resistance to azithromycin in a heterosexual woman in her 20s in France. Treatment with ceftriaxone plus doxycycline failed for the pharyngeal localisation. Whole-genome sequencing of isolate F90 identified MLST1903, NG-MAST ST3435, NG-STAR233, and relevant resistance determinants. F90 showed phenotypic and genotypic simila ...[more]

PMID: 29845928

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