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Multidrug-resistant Neisseria gonorrhoeae infection with ceftriaxone resistance and intermediate resistance to azithromycin, Denmark, 2017.

ABSTRACT: We describe a multidrug-resistant Neisseria gonorrhoeae infection with ceftriaxone resistance and azithromycin intermediate resistance in a heterosexual man in Denmark, 2017. Whole genome sequencing of the strain GK124 identified MSLT ST1903, NG-MAST ST1614 and all relevant resistance determinants including similar penA resistance mutations previously described in ceftriaxone-resistant gonococcal strains. Although treatment with ceftriaxone 0.5 g plus azithromycin 2 g was successful, increased awareness of spread of gonococcal strains threatening the recommended dual therapy is crucial.

SUBMITTER: Terkelsen D 

PROVIDER: S-EPMC5710115 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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Multidrug-resistant <i>Neisseria gonorrhoeae</i> infection with ceftriaxone resistance and intermediate resistance to azithromycin, Denmark, 2017.

Terkelsen David D   Tolstrup Jacob J   Johnsen Camilla Hundahl CH   Lund Ole O   Larsen Helle Kiellberg HK   Worning Peder P   Unemo Magnus M   Westh Henrik H  

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 20171001 42

We describe a multidrug-resistant <i>Neisseria gonorrhoeae</i> infection with ceftriaxone resistance and azithromycin intermediate resistance in a heterosexual man in Denmark, 2017. Whole genome sequencing of the strain GK124 identified MSLT ST1903, NG-MAST ST1614 and all relevant resistance determinants including similar penA resistance mutations previously described in ceftriaxone-resistant gonococcal strains. Although treatment with ceftriaxone 0.5 g plus azithromycin 2 g was successful, incr  ...[more]

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