Ontology highlight
ABSTRACT:
SUBMITTER: Shang R
PROVIDER: S-EPMC3871055 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Shang Ruofeng R Wang Shengyu S Xu Ximing X Yi Yunpeng Y Guo Wenzhu W Yuliu Liang Jianping J
PloS one 20131223 12
Novel pleuromutilin derivatives designed based on the structure of valnemulin were synthesized and evaluated for their in vitro antibacterial activities. These pleuromutilin derivatives with substituted amino moiety exhibited excellent activities against methicillin-resistant Staphylococcus aureus, methicillin-resistant Staphylococcus epidermidis, Escherichia coli, and Streptococcus agalactiae. Compound 5b showed the highest antibacterial activities and even exceeded tiamulin. Moreover, the dock ...[more]