Ontology highlight
ABSTRACT:
SUBMITTER: Chan LY
PROVIDER: S-EPMC6152797 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Chan Leon Y LY Mugler Christopher F CF Heinrich Stephanie S Vallotton Pascal P Weis Karsten K
eLife 20180907
The cytoplasmic abundance of mRNAs is strictly controlled through a balance of production and degradation. Whereas the control of mRNA synthesis through transcription has been well characterized, less is known about the regulation of mRNA turnover, and a consensus model explaining the wide variations in mRNA decay rates remains elusive. Here, we combine non-invasive transcriptome-wide mRNA production and stability measurements with selective and acute perturbations to demonstrate that mRNA degra ...[more]