Using Mendelian Randomization to Decipher Mechanisms of Bone Disease.
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ABSTRACT:
SUBMITTER: Trajanoska K
PROVIDER: S-EPMC6153565 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Publications
Using Mendelian Randomization to Decipher Mechanisms of Bone Disease.
Trajanoska Katerina K Rivadeneira Fernando F
Current osteoporosis reports 20181001 5
<h4>Purpose of review</h4>This review summarizes the basic principles of Mendelian randomization (MR) and provides evidence for the causal effect of multiple modifiable factors on bone outcomes.<h4>Recent findings</h4>Several studies using MR approach have provided support for the causal effect of obesity on bone mineral density (BMD). Strikingly, studies have failed to prove a causal association between elevated 25(OH) D concentrations and higher BMD in community-dwelling individuals. The MR ap ...[more]
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