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Adult height, coronary heart disease and stroke: a multi-locus Mendelian randomization meta-analysis.


ABSTRACT: We investigated causal effect of completed growth, measured by adult height, on coronary heart disease (CHD), stroke and cardiovascular traits, using instrumental variable (IV) Mendelian randomization meta-analysis.We developed an allele score based on 69 single nucleotide polymorphisms (SNPs) associated with adult height, identified by the IBCCardioChip, and used it for IV analysis against cardiovascular risk factors and events in 21 studies and 60 028 participants. IV analysis on CHD was supplemented by summary data from 180 height-SNPs from the GIANT consortium and their corresponding CHD estimates derived from CARDIoGRAMplusC4D.IV estimates from IBCCardioChip and GIANT-CARDIoGRAMplusC4D showed that a 6.5-cm increase in height reduced the odds of CHD by 10% [odds ratios 0.90; 95% confidence intervals (CIs): 0.78 to 1.03 and 0.85 to 0.95, respectively],which agrees with the estimate from the Emerging Risk Factors Collaboration (hazard ratio 0.93; 95% CI: 0.91 to 0.94). IV analysis revealed no association with stroke (odds ratio 0.97; 95% CI: 0.79 to 1.19). IV analysis showed that a 6.5-cm increase in height resulted in lower levels of body mass index ( P  < 0.001), triglycerides ( P  < 0.001), non high-density (non-HDL) cholesterol ( P  < 0.001), C-reactive protein ( P  = 0.042), and systolic blood pressure ( P  = 0.064) and higher levels of forced expiratory volume in 1 s and forced vital capacity ( P  < 0.001 for both).Taller individuals have a lower risk of CHD with potential explanations being that taller people have a better lung function and lower levels of body mass index, cholesterol and blood pressure.

SUBMITTER: Nuesch E 

PROVIDER: S-EPMC5841831 | biostudies-other | 2016 Dec

REPOSITORIES: biostudies-other

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Adult height, coronary heart disease and stroke: a multi-locus Mendelian randomization meta-analysis.

Nüesch Eveline E   Dale Caroline C   Palmer Tom M TM   White Jon J   Keating Brendan J BJ   van Iperen Erik Pa EP   Goel Anuj A   Padmanabhan Sandosh S   Asselbergs Folkert W FW   Verschuren W M WM   Wijmenga C C   Van der Schouw Y T YT   Onland-Moret N C NC   Lange Leslie A LA   Hovingh G K GK   Sivapalaratnam Suthesh S   Morris Richard W RW   Whincup Peter H PH   Wannamethe Goya S GS   Gaunt Tom R TR   Ebrahim Shah S   Steel Laura L   Nair Nikhil N   Reiner Alexander P AP   Kooperberg Charles C   Wilson James F JF   Bolton Jennifer L JL   McLachlan Stela S   Price Jacqueline F JF   Strachan Mark Wj MW   Robertson Christine M CM   Kleber Marcus E ME   Delgado Graciela G   März Winfried W   Melander Olle O   Dominiczak Anna F AF   Farrall Martin M   Watkins Hugh H   Leusink Maarten M   Maitland-van der Zee Anke H AH   de Groot Mark Ch MC   Dudbridge Frank F   Hingorani Aroon A   Ben-Shlomo Yoav Y   Lawlor Debbie A DA   Amuzu A A   Caufield M M   Cavadino A A   Cooper J J   Davies T L TL   Drenos F F   Engmann J J   Finan C C   Giambartolomei C C   Hardy R R   Humphries S E SE   Hypponen E E   Kivimaki M M   Kuh D D   Kumari M M   Ong K K   Plagnol V V   Power C C   Richards M M   Shah S S   Shah T T   Sofat R R   Talmud P J PJ   Wareham N N   Warren H H   Whittaker J C JC   Wong A A   Zabaneh D D   Davey Smith George G   Wells Jonathan C JC   Leon David A DA   Holmes Michael V MV   Casas Juan P JP  

International journal of epidemiology 20161201 6


<h4>Background</h4>We investigated causal effect of completed growth, measured by adult height, on coronary heart disease (CHD), stroke and cardiovascular traits, using instrumental variable (IV) Mendelian randomization meta-analysis.<h4>Methods</h4>We developed an allele score based on 69 single nucleotide polymorphisms (SNPs) associated with adult height, identified by the IBCCardioChip, and used it for IV analysis against cardiovascular risk factors and events in 21 studies and 60 028 partici  ...[more]

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