Ontology highlight
ABSTRACT:
SUBMITTER: Peloquin CA
PROVIDER: S-EPMC6153781 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Antimicrobial agents and chemotherapy 20180924 10
Patients with multidrug-resistant tuberculosis in Peru and South Africa were randomized to a weight-banded nominal dose of 11, 14, 17, or 20 mg/kg/day levofloxacin (minimum, 750 mg) in combination with other second-line agents. A total of 101 patients were included in noncompartmental pharmacokinetic analyses. Respective median areas under the concentration-time curve from 0 to 24 h (AUC<sub>0-24</sub>) were 109.49, 97.86, 145.33, and 207.04 μg · h/ml. Median maximum plasma concentration (<i>C</ ...[more]