Ontology highlight
ABSTRACT:
SUBMITTER: Krishnan P
PROVIDER: S-EPMC6153825 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Krishnan Preethi P Pilot-Matias Tami T Schnell Gretja G Tripathi Rakesh R Ng Teresa I TI Reisch Thomas T Beyer Jill J Dekhtyar Tatyana T Irvin Michelle M Xie Wangang W Larsen Lois L Mensa Federico J FJ Collins Christine C
Antimicrobial agents and chemotherapy 20180924 10
Over 2,200 patients infected with hepatitis C virus (HCV) genotypes (GT) 1 to 6, with or without cirrhosis, who were treatment naive or experienced to interferon, ribavirin, and/or sofosbuvir were treated with glecaprevir/pibrentasvir for 8, 12, or 16 weeks in eight registrational phase 2 and 3 clinical studies. High rates of sustained virologic response at 12 weeks postdosing (SVR12) were achieved with a <1% virologic failure (VF) rate. The prevalence of baseline polymorphisms (BPs) in NS3 at a ...[more]