Ontology highlight
ABSTRACT:
SUBMITTER: Wang R
PROVIDER: S-EPMC6154017 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Wang Ruoxi R Hao Wenjing W Pan Lang L Boldogh Istvan I Ba Xueqing X
Cellular and molecular life sciences : CMLS 20180724 20
Modifications of DNA strands and nucleobases-both induced and accidental-are associated with unfavorable consequences including loss or gain in genetic information and mutations. Therefore, DNA repair proteins have essential roles in keeping genome fidelity. Recently, mounting evidence supports that 8-oxoguanine (8-oxoG), one of the most abundant genomic base modifications generated by reactive oxygen and nitrogen species, along with its cognate repair protein 8-oxoguanine DNA glycosylase1 (OGG1 ...[more]