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Visible-Light Photocatalytic Difluoroalkylation-Induced 1, 2-Heteroarene Migration of Allylic Alcohols in Batch and Flow.

ABSTRACT: A convenient method for the preparation of sp³-rich heterocycles is reported. The method comprises a photocatalytic difluoroalkylation-induced 1,2-heteroarene migration of allylic alcohols. Here we describe for the first time the benefits of using flow to facilitate such migration reactions, including shorter reaction times, higher selectivities, and opportunities to scale the chemistry.

SUBMITTER: Wei XJ

PROVIDER: S-EPMC6154216 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Visible-Light Photocatalytic Difluoroalkylation-Induced 1, 2-Heteroarene Migration of Allylic Alcohols in Batch and Flow.

Wei Xiao-Jing XJ Noël Timothy T

The Journal of organic chemistry 20180727 18

A convenient method for the preparation of sp<sup>3</sup>-rich heterocycles is reported. The method comprises a photocatalytic difluoroalkylation-induced 1,2-heteroarene migration of allylic alcohols. Here we describe for the first time the benefits of using flow to facilitate such migration reactions, including shorter reaction times, higher selectivities, and opportunities to scale the chemistry. ...[more]

PMID: 30020781

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