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Isolaurenidificin and Bromlaurenidificin, Two New C₁₅-Acetogenins from the Red Alga Laurencia obtusa.

ABSTRACT: Chromatographic fractionation of the CH?Cl?/MeOH extract of the Red Sea red alga Laurencia obtusa gave two new hexahydrofuro[3,2-b]furan-based C₁₅-acetogenins, namely, isolaurenidificin (1) and bromlaurenidificin (2). The chemical structures were elucidated based on extensive analyses of their spectral data. Compounds 1 and 2 showed no toxicity (LC₅₀ > 12 mM) using Artemia salina as test organism. Both compounds showed weak cytotoxicity against A549, HepG-2, HCT116, MCF-7, and PC-3 cells, however, they exhibited a relatively potent cytotoxic activity against peripheral blood neutrophils. This can be attributed partly to induction of apoptosis.

SUBMITTER: Bawakid NO

PROVIDER: S-EPMC6154321 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Isolaurenidificin and Bromlaurenidificin, Two New C15-Acetogenins from the Red Alga Laurencia obtusa.

Bawakid Nahed O NO Alarif Walied M WM Alburae Najla A NA Alorfi Hajer S HS Al-Footy Khalid O KO Al-Lihaibi Sultan S SS Ghandourah Mohamed A MA

Molecules (Basel, Switzerland) 20170515 5

Chromatographic fractionation of the CH₂Cl₂/MeOH extract of the Red Sea red alga Laurencia obtusa gave two new hexahydrofuro[3,2-b]furan-based C15-acetogenins, namely, isolaurenidificin (1) and bromlaurenidificin (2). The chemical structures were elucidated based on extensive analyses of their spectral data. Compounds 1 and 2 showed no toxicity (LC50 > 12 mM) using Artemia salina as test organism. Both compounds showed ...[more]

PMID: 28505125

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