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Synthesis of Curcuminoids and Evaluation of Their Cytotoxic and Antioxidant Properties.

ABSTRACT: Curcumin (1) and ten derivatives (2-11) were synthesized and evaluated as cytotoxic and antioxidant agents. The results of primary screening by Sulforhodamine B assay against five human cancer cell lines (U-251 MG, glioblastoma; PC-3, human prostatic; HCT-15, human colorectal; K562, human chronic myelogenous leukemia; and SKLU-1, non-small cell lung cancer) allowed us to calculate the half maximal inhibitory concentration (IC₅₀) values for the more active compounds against HCT-15 and K562 cell lines. Compounds 2 and 10 were the most active against both cell lines and were more active than curcumin itself. Thiobarbituric acid reactive substances (TBARS) assay showed that 7 has potent activity; even stronger than curcumin, ?-tocopherol, and quercetin.

SUBMITTER: Lozada-Garcia MC

PROVIDER: S-EPMC6154528 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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Synthesis of Curcuminoids and Evaluation of Their Cytotoxic and Antioxidant Properties.

Lozada-García María Concepción MC Enríquez Raúl G RG Ramírez-Apán Teresa O TO Nieto-Camacho Antonio A Palacios-Espinosa Juan Francisco JF Custodio-Galván Zeltzin Z Soria-Arteche Olivia O Pérez-Villanueva Jaime J

Molecules (Basel, Switzerland) 20170414 4

Curcumin (1) and ten derivatives (2-11) were synthesized and evaluated as cytotoxic and antioxidant agents. The results of primary screening by Sulforhodamine B assay against five human cancer cell lines (U-251 MG, glioblastoma; PC-3, human prostatic; HCT-15, human colorectal; K562, human chronic myelogenous leukemia; and SKLU-1, non-small cell lung cancer) allowed us to calculate the half maximal inhibitory concentration (IC50) values for the more active compound ...[more]

PMID: 28420097

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Synthesis of Curcuminoids and Evaluation of Their Cytotoxic and Antioxidant Properties.

Publications

Synthesis of Curcuminoids and Evaluation of Their Cytotoxic and Antioxidant Properties.

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