Ontology highlight
ABSTRACT:
SUBMITTER: Kim HN
PROVIDER: S-EPMC6154572 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20170515 5
Heparin and heparan sulfate are structurally-related carbohydrates with therapeutic applications in anticoagulation, drug delivery, and regenerative medicine. This study explored the effect of different bioreactor conditions on the production of heparin/heparan sulfate chains via the recombinant expression of serglycin in mammalian cells. Tissue culture flasks and continuously-stirred tank reactors promoted the production of serglycin decorated with heparin/heparan sulfate, as well as chondroiti ...[more]