Ontology highlight
ABSTRACT:
SUBMITTER: Mandal M
PROVIDER: S-EPMC6155124 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Mandal Malay M Maienschein-Cline Mark M Maffucci Patrick P Veselits Margaret M Kennedy Domenick E DE McLean Kaitlin C KC Okoreeh Michael K MK Karki Sophiya S Cunningham-Rundles Charlotte C Clark Marcus R MR
Nature communications 20180924 1
Transcription factor (TF) networks determine cell fate in hematopoiesis. However, how TFs cooperate with other regulatory mechanisms to instruct transcription remains poorly understood. Here we show that in small pre-B cells, the lineage restricted epigenetic reader BRWD1 closes early development enhancers and opens the enhancers of late B lymphopoiesis to TF binding. BRWD1 regulates over 7000 genes to repress proliferative and induce differentiation programs. However, BRWD1 does not regulate th ...[more]