Ontology highlight
ABSTRACT:
SUBMITTER: Fernandes LM
PROVIDER: S-EPMC6155149 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Fernandes Lorenzo M LM Al-Dwairi Ahmed A Simmen Rosalia C M RCM Marji Meera M Brown Dustin M DM Jewell Sarah W SW Simmen Frank A FA
Scientific reports 20180924 1
Cytosolic Malic Enzyme (ME1) provides reduced NADP for anabolism and maintenance of redox status. To examine the role of ME1 in tumor genesis of the gastrointestinal tract, we crossed mice having augmented intestinal epithelial expression of ME1 (ME1-Tg mice) with Apc<sup>Min/+</sup> mice to obtain male Apc<sup>Min/+</sup>/ME1-Tg mice. ME1 protein levels were significantly greater within gut epithelium and adenomas of male Apc<sup>Min/+</sup>/ME1-Tg than Apc<sup>Min/+</sup> mice. Male Apc<sup>Mi ...[more]