Ontology highlight
ABSTRACT:
SUBMITTER: Stefanoska K
PROVIDER: S-EPMC6155170 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Stefanoska Kristie K Bertz Josefine J Volkerling Alexander M AM van der Hoven Julia J Ittner Lars M LM Ittner Arne A
Scientific reports 20180924 1
Modulation of behavioural responses by neuronal signalling pathways remains incompletely understood. Signalling via mitogen-activated protein (MAP) kinase cascades regulates multiple neuronal functions. Here, we show that neuronal p38α, a MAP kinase of the p38 kinase family, has a critical and specific role in modulating anxiety-related behaviour in mice. Neuron-specific p38α-knockout mice show increased levels of anxiety in behaviour tests, yet no other behavioural, cognitive or motor deficits. ...[more]