Ontology highlight
ABSTRACT:
SUBMITTER: Zhou K
PROVIDER: S-EPMC6155247 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Zhou Kai K Yao Yue-Liang YL He Zhi-Cheng ZC Chen Cong C Zhang Xiao-Ning XN Yang Kai-Di KD Liu Yu-Qi YQ Liu Qing Q Fu Wen-Juan WJ Chen Ya-Ping YP Niu Qin Q Ma Qing-Hua QH Zhou Rong R Yao Xiao-Hong XH Zhang Xia X Cui You-Hong YH Bian Xiu-Wu XW Shi Yu Y Ping Yi-Fang YF
Cell death & disease 20180924 10
Plastic phenotype convention between glioma stem cells (GSCs) and non-stem tumor cells (NSTCs) significantly fuels glioblastoma heterogeneity that causes therapeutic failure. Recent progressions indicate that glucose metabolic reprogramming could drive cell fates. However, the metabolic pattern of GSCs and NSTCs and its association with tumor cell phenotypes remain largely unknown. Here we found that GSCs were more glycolytic than NSTCs, and voltage-dependent anion channel 2 (VDAC2), a mitochond ...[more]