DNA methylation derived systemic inflammation indices are associated with head and neck cancer development and survival.

ABSTRACT:

Objectives

Head and neck squamous cell carcinoma (HNSCC) is often associated with chronic systemic inflammation (SI). In the present study, we assessed if DNA methylation-derived SI (mdSI) indices: Neutrophil-to-Lymphocyte ratio (mdNLR) and Lymphocyte-to-Monocyte ratio (mdLMR) are associated with the presence of HNSCC and overall survival (OS).

Materials and methods

We used two peripheral blood DNA methylation datasets: an HNSCC case-control dataset (n = 183) and an HNSCC survival dataset (n = 407) to estimate mdSI indices. We then performed multivariate regressions to test the association between mdSI indices, HNSCC development and OS.

Results

Multivariate logistic regression revealed that elevated mdNLR was associated with increased odds of being an HNSCC case (OR =

SUBMITTER: Ambatipudi S 

PROVIDER: S-EPMC6156796 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature