Unknown

Dataset Information

0

DNA Methylation Changes in Human Papillomavirus-Driven Head and Neck Cancers.

ABSTRACT: Disruption of DNA methylation patterns is one of the hallmarks of cancer. Similar to other cancer types, human papillomavirus (HPV)-driven head and neck cancer (HNC) also reveals alterations in its methylation profile. The intrinsic ability of HPV oncoproteins E6 and E7 to interfere with DNA methyltransferase activity contributes to these methylation changes. There are many genes that have been reported to be differentially methylated in HPV-driven HNC. Some of these genes are involved in major cellular pathways, indicating that DNA methylation, at least in certain instances, may contribute to the development and progression of HPV-driven HNC. Furthermore, the HPV genome itself becomes a target of the cellular DNA methylation machinery. Some of these methylation changes appearing in the viral long control region (LCR) may contribute to uncontrolled oncoprotein expression, leading to carcinogenesis. Consistent with these observations, demethylation therapy appears to have significant effects on HPV-driven HNC. This review article comprehensively summarizes DNA methylation changes and their diagnostic and therapeutic indications in HPV-driven HNC.

SUBMITTER: Ekanayake Weeramange C 

PROVIDER: S-EPMC7348958 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

DNA Methylation Changes in Human Papillomavirus-Driven Head and Neck Cancers.

Ekanayake Weeramange Chameera C   Tang Kai Dun KD   Vasani Sarju S   Langton-Lockton Julian J   Kenny Liz L   Punyadeera Chamindie C  

Cells 20200531 6

Disruption of DNA methylation patterns is one of the hallmarks of cancer. Similar to other cancer types, human papillomavirus (HPV)-driven head and neck cancer (HNC) also reveals alterations in its methylation profile. The intrinsic ability of HPV oncoproteins E6 and E7 to interfere with DNA methyltransferase activity contributes to these methylation changes. There are many genes that have been reported to be differentially methylated in HPV-driven HNC. Some of these genes are involved in major  ...[more]

Similar Datasets

Unknown Characterization of the methylation patterns in human papillomavirus type 16 viral DNA in head and neck cancers.
| S-EPMC3079312 | biostudies-literature
Unknown Vaccine Strategies for Human Papillomavirus-Associated Head and Neck Cancers.
| S-EPMC8750601 | biostudies-literature
Unknown Human papillomavirus-driven head and neck cancers in Japan during 2008-2009 and 2018-2019: The BROADEN study.
| S-EPMC11309946 | biostudies-literature
Unknown Survival-Associated Metabolic Genes in Human Papillomavirus-Positive Head and Neck Cancers.
| S-EPMC7017314 | biostudies-literature
Unknown Gene Expression and DNA Methylation in Human Papillomavirus Positive and Negative Head and Neck Squamous Cell Carcinomas.
| S-EPMC9504918 | biostudies-literature
Unknown Fundamental differences in cell cycle deregulation in human papillomavirus-positive and human papillomavirus-negative head/neck and cervical cancers.
| S-EPMC2858285 | biostudies-literature
Unknown Biological Features of Human Papillomavirus-related Head and Neck Cancers Contributing to Improved Response.
| S-EPMC5512583 | biostudies-literature
Unknown Innovative DNA vaccine for human papillomavirus (HPV)-associated head and neck cancer.
| S-EPMC3032008 | biostudies-literature
Unknown Prevalence of human papillomavirus in head and neck cancers in European populations: a meta-analysis.
| S-EPMC4320477 | biostudies-literature
Unknown CYLD Alterations in the Tumorigenesis and Progression of Human Papillomavirus-Associated Head and Neck Cancers.
| S-EPMC7840145 | biostudies-literature