Improved enzyme annotation with EC-specific cutoffs using DETECT v2.
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ABSTRACT:
SUBMITTER: Nursimulu N
PROVIDER: S-EPMC6157075 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Publications
Improved enzyme annotation with EC-specific cutoffs using DETECT v2.
Nursimulu Nirvana N Xu Leon L LL Wasmuth James D JD Krukov Ivan I Parkinson John J
Bioinformatics (Oxford, England) 20181001 19
<h4>Summary</h4>We present DETECT v2-an enzyme annotation tool which considers the effect of sequence diversity when assigning enzymatic function [as an Enzyme Commission (EC) number] to a protein sequence. In addition to capturing more enzyme classes than the previous version, we now provide EC-specific cutoffs that greatly increase precision and recall of assignments and show its performance in the context of pathways.<h4>Availability and implementation</h4>https://github.com/ParkinsonLab/DETE ...[more]
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