Ontology highlight
ABSTRACT:
SUBMITTER: Castresana-Aguirre M
PROVIDER: S-EPMC7423893 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Castresana-Aguirre Miguel M Sonnhammer Erik L L ELL
Scientific reports 20200812 1
Pathway enrichment analysis is the most common approach for understanding which biological processes are affected by altered gene activities under specific conditions. However, it has been challenging to find a method that efficiently avoids false positives while keeping a high sensitivity. We here present a new network-based method ANUBIX based on sampling random gene sets against intact pathway. Benchmarking shows that ANUBIX is considerably more accurate than previous network crosstalk based ...[more]