Ontology highlight
ABSTRACT:
SUBMITTER: van Esdonk MJ
PROVIDER: S-EPMC6157667 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
van Esdonk Michiel J MJ Lindeman Ian I Okkerse Pieter P de Kam Marieke L ML Groeneveld Geert J GJ Stevens Jasper J
CPT: pharmacometrics & systems pharmacology 20180813 9
A battery of pain models can be used in clinical trials to investigate the efficacy and to establish the concentration-effect relationship of novel analgesics. This study quantified the pharmacokinetics (PK) of pregabalin after a single oral dose of 300 mg and the pharmacodynamics (PD) on the pain tolerance threshold (PTT) of the cold pressor, electrical stimulation, the pressure pain model, and on the pain detection threshold of a contact heat pain model. The PK were best described using a one- ...[more]