Ontology highlight
ABSTRACT:
SUBMITTER: Guiastrennec B
PROVIDER: S-EPMC6157686 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Guiastrennec Benjamin B Sonne David P DP Bergstrand Martin M Vilsbøll Tina T Knop Filip K FK Karlsson Mats O MO
CPT: pharmacometrics & systems pharmacology 20180812 9
Bile acids released postprandially can modify the rate and extent of lipophilic compounds' absorption. This study aimed to predict the enterohepatic circulation (EHC) of total bile acids (TBAs) in response to caloric intake from their spillover in plasma. A model for TBA EHC was combined with a previously developed gastric emptying (GE) model. Longitudinal gallbladder volumes and TBA plasma concentration data from 30 subjects studied after ingestion of four different test drinks were supplemente ...[more]