Methylation deregulation of miRNA promoters identifies miR124-2 as a survival biomarker in Breast Cancer in very young women.
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ABSTRACT:
SUBMITTER: Oltra SS
PROVIDER: S-EPMC6158237 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Publications
Methylation deregulation of miRNA promoters identifies miR124-2 as a survival biomarker in Breast Cancer in very young women.
Oltra Sara S SS Peña-Chilet Maria M Vidal-Tomas Victoria V Flower Kirsty K Martinez María Teresa MT Alonso Elisa E Burgues Octavio O Lluch Ana A Flanagan James M JM Ribas Gloria G
Scientific reports 20180926 1
MiRNAs are part of the epigenetic machinery, and are also epigenetically modified by DNA methylation. MiRNAs regulate expression of different genes, so any alteration in their methylation status may affect their expression. We aimed to identify methylation differences in miRNA encoding genes in breast cancer affecting women under 35 years old (BCVY), in order to identify potential biomarkers in these patients. In Illumina Infinium MethylationEPIC BeadChip samples (metEPICVal), we analysed the me ...[more]
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