Acceleration in the DNA methylation age in breast cancer tumours from very young women.
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ABSTRACT:
SUBMITTER: Oltra SS
PROVIDER: S-EPMC6800453 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Publications
Acceleration in the DNA methylation age in breast cancer tumours from very young women.
Oltra Sara S SS Peña-Chilet Maria M Flower Kirsty K Martinez María Teresa MT Alonso Elisa E Burgues Octavio O Lluch Ana A Flanagan James M JM Ribas Gloria G
Scientific reports 20191018 1
Breast cancer in very young women (≤35 years; BCVY) presents more aggressive and complex biological features than their older counterparts (BCO). Our aim was to evaluate methylation differences between BCVY and BCO and their DNA epigenetic age. EPIC and 450k Illumina methylation arrays were used in 67 breast cancer tumours, including 32 from BCVY, for methylation study and additionally we analysed their epigenetic age. We identified 2 219 CpG sites differently-methylated in BCVY vs. BCO (FDR < 0 ...[more]
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