Ontology highlight
ABSTRACT:
SUBMITTER: Giebler M
PROVIDER: S-EPMC6158399 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Giebler Maria M Greither Thomas T Behre Hermann M HM
Frontiers in genetics 20180920
<i>PIWI-LIKE 2</i>, a member of the ARGONAUTE protein family, is exclusively expressed in pre-pachytene and pachytene stages of spermatogenesis. <i>PIWI-LIKE 2</i> acts in the germ cell development and the silencing of retrotransponsons to maintain the genomic integrity and stem cell character. In the present study we investigated DNA methylation as potential mechanism for the regulation of human <i>PIWI-LIKE 2</i> expression in cell lines related to spermatozoa precursor cells. We detected a hi ...[more]